A Novel Bacterial Artificial Chromosome-Transgenic Podoplanin–Cre Mouse Targets Lymphoid Organ Stromal Cells in vivo
Identifieur interne : 005138 ( Main/Exploration ); précédent : 005137; suivant : 005139A Novel Bacterial Artificial Chromosome-Transgenic Podoplanin–Cre Mouse Targets Lymphoid Organ Stromal Cells in vivo
Auteurs : Lucas Onder [Suisse] ; Elke Scandella [Suisse] ; Qian Chai [Suisse] ; Sonja Firner [Suisse] ; Christian T. Mayer [Allemagne] ; Tim Sparwasser [Allemagne] ; Volker Thiel [Suisse] ; Thomas Rülicke [Autriche] ; Burkhard Ludewig [Suisse]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2011.
Abstract
Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation of antigen. Despite significant gain of knowledge on the biology of different SLO-resident stromal cell subsets, their molecular and functional characterization has remained incomplete. To address this need, we have generated a bacterial artificial chromosome-transgenic mouse model that utilizes the podoplanin (pdpn) promoter to express the Cre-recombinase exclusively in stromal cells of SLOs. The characterization of the Pdpn–Cre mouse revealed transgene expression in subsets of fibroblastic reticular cells and lymphatic endothelial cells in LNs. Furthermore, the transgene facilitated the identification of a novel splenic perivascular stromal cell subpopulation that forms web-like structures around central arterioles. Assessment of the
Url:
DOI: 10.3389/fimmu.2011.00050
PubMed: 22566840
PubMed Central: 3342134
Affiliations:
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Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author><author><name sortKey="Firner, Sonja" sort="Firner, Sonja" uniqKey="Firner S" first="Sonja" last="Firner">Sonja Firner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Immunobiology, Cantonal Hospital St. Gallen</institution><country>St. Gallen, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, Christian T" sort="Mayer, Christian T" uniqKey="Mayer C" first="Christian T." last="Mayer">Christian T. Mayer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Infection Immunology, TWINCORE, Hannover Medical School</institution><country>Hannover, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion><wicri:noRegion>Lawrenceville</wicri:noRegion><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author><author><name sortKey="Sparwasser, Tim" sort="Sparwasser, Tim" uniqKey="Sparwasser T" first="Tim" last="Sparwasser">Tim Sparwasser</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Infection Immunology, TWINCORE, Hannover Medical School</institution><country>Hannover, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion><wicri:noRegion>Lawrenceville</wicri:noRegion><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Immunobiology, Cantonal Hospital St. Gallen</institution><country>St. Gallen, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author><author><name sortKey="Rulicke, Thomas" sort="Rulicke, Thomas" uniqKey="Rulicke T" first="Thomas" last="Rülicke">Thomas Rülicke</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institute of Laboratory Animal Science and Biomodels Austria, University of Veterinary Medicine Vienna</institution><country>Vienna, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author><author><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Immunobiology, Cantonal Hospital St. Gallen</institution><country>St. Gallen, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea><wicri:noRegion>Lawrenceville</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation of antigen. Despite significant gain of knowledge on the biology of different SLO-resident stromal cell subsets, their molecular and functional characterization has remained incomplete. To address this need, we have generated a bacterial artificial chromosome-transgenic mouse model that utilizes the podoplanin (pdpn) promoter to express the Cre-recombinase exclusively in stromal cells of SLOs. The characterization of the Pdpn–Cre mouse revealed transgene expression in subsets of fibroblastic reticular cells and lymphatic endothelial cells in LNs. Furthermore, the transgene facilitated the identification of a novel splenic perivascular stromal cell subpopulation that forms web-like structures around central arterioles. Assessment of the <italic>in vivo</italic> antigen expression in the genetically tagged stromal cells in Pdpn–Cre mice revealed activation of both MHC I and II-restricted TCR transgenic T cells. Taken together, stromal pdpn–Cre expression is well-suited to characterize the phenotype and to dissect the function of lymphoid organ stromal cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bajenoff, M" uniqKey="Bajenoff M">M. Bajenoff</name></author><author><name sortKey="Egen, J G" uniqKey="Egen J">J. G. Egen</name></author><author><name sortKey="Koo, L Y" uniqKey="Koo L">L. Y. Koo</name></author><author><name sortKey="Laugier, J P" uniqKey="Laugier J">J. P. Laugier</name></author><author><name sortKey="Brau, F" uniqKey="Brau F">F. Brau</name></author><author><name sortKey="Glaichenhaus, N" uniqKey="Glaichenhaus N">N. Glaichenhaus</name></author><author><name sortKey="Germain, R N" uniqKey="Germain R">R. N. 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Tumanov</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Onder, Lucas" sort="Onder, Lucas" uniqKey="Onder L" first="Lucas" last="Onder">Lucas Onder</name></noRegion><name sortKey="Chai, Qian" sort="Chai, Qian" uniqKey="Chai Q" first="Qian" last="Chai">Qian Chai</name><name sortKey="Firner, Sonja" sort="Firner, Sonja" uniqKey="Firner S" first="Sonja" last="Firner">Sonja Firner</name><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name><name sortKey="Scandella, Elke" sort="Scandella, Elke" uniqKey="Scandella E" first="Elke" last="Scandella">Elke Scandella</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name></country><country name="Allemagne"><noRegion><name sortKey="Mayer, Christian T" sort="Mayer, Christian T" uniqKey="Mayer C" first="Christian T." last="Mayer">Christian T. Mayer</name></noRegion><name sortKey="Sparwasser, Tim" sort="Sparwasser, Tim" uniqKey="Sparwasser T" first="Tim" last="Sparwasser">Tim Sparwasser</name></country><country name="Autriche"><noRegion><name sortKey="Rulicke, Thomas" sort="Rulicke, Thomas" uniqKey="Rulicke T" first="Thomas" last="Rülicke">Thomas Rülicke</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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